Cardiovascular Trials and Other Research Studies

Cardiovascular Trials and Other Research Studies

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Alcohol and Your Heart

Over the last three decades, a number of studies have shown an association between moderate drinking and a lowered risk for heart attack, heart and circulatory diseases, stroke, type 2 diabetes, and gallstones.

But the research results lead to a kind of two-edged sword when it comes to alcohol. Alcohol may have some health benefits, but it may also lead to abusive drinking and other diseases. Because there is no sure way to know who will develop an abuse problem, the American Heart Association (AHA) and other experts don't recommend starting to drink if you don't already do so but to talk with your health care provider about the benefits and risks of moderate alcohol use.

Learn the meaning of moderation

Moderate drinking is defined as no more than one drink a day for women and two drinks a day for men. Pregnant women should avoid all alcohol as it can lead to birth defects. A drink is considered 12 ounces of regular beer, 4 to 5 ounces of wine, or 1.5 ounces of 80-proof distilled spirits.

Moderation is defined differently for men, women, and older adults because alcohol’s effects depend on how the body absorbs and metabolizes alcohol. Older adults metabolize, or break down, alcohol more slowly than younger people. This means alcohol stays in their bodies longer. A person's height and weight are critical in alcohol absorption. The smaller and lighter you are, the more quickly alcohol is absorbed.

Know how you react to alcohol

People respond differently to alcohol for other reasons besides height and weight. Your gender, age, genetics, overall health, the amount of alcohol you drink, when you drink it, and any history of problem drinking can affect your reaction to alcohol.

When alcohol is consumed, it passes from the stomach and small intestine into the blood and is transported to all organs of the body. Alcohol is water soluble, so it enters your organs in proportion to the amount of water they contain. The more water available in the organs to absorb alcohol, the less alcohol remains in your bloodstream.

Your liver does most of the work of breaking down, or metabolizing, the alcohol you drink. The liver removes alcohol from your body so it won't damage other organs. The liver can break down only a certain amount of alcohol per hour, regardless of the amount you drink. A very small percentage of alcohol escapes this metabolic process and is eliminated unchanged in your breath, sweat and urine. (This alcohol can be detected in a breathalyzer test.) Until all the alcohol in the body has been metabolized, it stays in the brain and other tissues of the body and continues to cause effects.

Men vs. women

In general, women and older men have less water in their organs than younger men. Therefore, less alcohol enters their organs and more alcohol remains in their bloodstream. Younger women produce less of a stomach enzyme called alcohol dehydrogenase, which breaks down alcohol in the stomach. This means more alcohol is available to be absorbed into the blood. As a result, a young woman will have a higher blood alcohol level than a man of the same age who drinks the same amount of alcohol.

Heredity may play a role in how alcohol and your body interact. Moderate drinkers who have genes that cause a slower metabolism of alcohol are at much lower risk for cardiovascular disease than moderate drinkers who have genes that cause rapid metabolism of alcohol.

Alcohol is metabolized more slowly than it is absorbed. Absorption is slowed when you drink alcohol during or immediately after a meal. The slower absorption allows the liver to metabolize alcohol at a rate that prevents more of it from reaching other organs.

Because the liver metabolizes alcohol, people with liver disease are more sensitive to drinking. Certain medications may trigger adverse reactions if you drink while taking them. Alcohol affects the metabolism of a wide variety of medications by increasing the activity of some and decreasing the activity of others. Most notably, heavy alcohol consumption when taking acetaminophen (Tylenol) can lead to liver damage. 

Additionally, for people with a history of alcoholism, the danger of drinking is far greater than the possible cardiovascular benefits.

Health benefits and concerns

The AHA says moderate alcohol consumption helps protect against heart disease by raising HDL ("good") cholesterol and reducing plaque accumulations in your arteries. Alcohol also has a mild anticoagulating effect, keeping platelets from clumping together to form blood clots. According to the National Council on Alcoholism and Drug Dependence, moderate drinking may lower the risk for coronary heart disease among men older than 45 and women older than 55. Moderate consumption provides little, if any, health benefit for younger people, and the risk of alcohol abuse increases when drinking starts at an early age. Remember that alcohol doesn't provide complete protection against heart disease or compensate for negative health habits like smoking, which lowers HDL and increases the risk of harmful blood clots.

Moreover, the AHA says, regular physical exercise also can raise HDL. And excessive drinking can raise triglyceride levels, increase blood pressure, and raise the risk for stroke.

Consider alcohol's caloric content

There's no fat in alcohol. That's the good news. But there are 7 calories per gram, and that translates to between 100 and 150 calories for the alcohol in a typical beer, wine, or spirits drink. Add to that the calories in drink mixers, and drinking could be a setup for weight gain.


Through the approval of the Broward Health Institutional Review Board, Broward Health Medical Center offers pharmaceutical-sponsored FDA-approved cardiovascular clinical trials to the community. These various pharmaceutical sponsored trials involve cutting-edge cardiovascular related areas to study cardiac disease, anticoagulants or antithrombotics, blood pressure control, cholesterol control, atrial fibrillation, interventional and cardiology, and diabetes, as well as cardiac device trials.

Cardiovascular clinical trial research is done to help doctors to find a better way to treat and diagnose patients with cardiac disease. The decision to enroll in a clinical trial is completely voluntary. Each trial offers its own opportunities and risks, but many research volunteers find that clinical trials offer these common benefits:

  • opportunity for health care provided by leading physicians in the field of cardiac research
  • access to new drugs and interventions before they are widely available
  • for you to have a more active role in your own health care
  • close monitoring of your health care and any side effects
  • you may be the first to benefit, if the approach being studied is found to be helpful to the disease being studied
  • an opportunity to make a valuable contribution to cardiac research

If you think that you may qualify for a study and wish to participate, call the senior research nurses at the cardiovascular research department. Please call Broward Health Medical Center Cardiovascular Research at 954-468-5237 and leave your name and number, along with the study name that you think that you may qualify for and a research nurse will contact you.

For further information, please visit:

Please call the Principal Investigator or Study coordinator with any questions or potential subjects.

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