Chris Evert Children's Hospital
Pediatric Sickle Cell Day Treatment and Wellness Center

Pediatric Sickle Cell Day Treatment and Wellness Center

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Hydroxyurea Oral capsule

What is this medicine?

HYDROXYUREA (hye drox ee yoor EE a) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat certain leukemias, skin cancer, head and neck cancer, and advanced ovarian cancer. It is also used to control the painful crises of sickle cell anemia.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • immune system problems

  • infection (especially a virus infection such as chickenpox, cold sores, or herpes)

  • kidney disease

  • low blood counts, like low white cell, platelet, or red cell counts

  • previous or ongoing radiation therapy

  • an unusual or allergic reaction to hydroxyurea, other chemotherapy, other medicines, foods, dyes, or preservatives

  • pregnant or trying to get pregnant

  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

People who are not taking this medicine should not be exposed to it. Wash your hands before and after handling your bottle or medicine. Caregivers should wear disposable gloves if they must touch the bottle or medicine. Clean up any medicine powder that spills with a damp disposable towel and throw the towel away in a closed container, such as a plastic bag.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • didanosine

  • other chemotherapy agents

  • stavudine

  • tenofovir

  • vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop. You will receive regular blood tests during your treatment.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Men should inform their doctors if they wish to father a child. This medicine may lower sperm counts. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue

  • low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.

  • signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine

  • signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine

  • signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness

  • breathing problems

  • burning, redness or pain at the site of any radiation therapy

  • changes in skin color

  • confusion

  • mouth sores

  • pain, tingling, numbness in the hands or feet

  • seizures

  • skin ulcers

  • trouble passing urine or change in the amount of urine

  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • headache

  • loss of appetite

  • red color to the face

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep tightly closed. Throw away any unused medicine after the expiration date.


Test TubesAt the Chris Evert Children’s Hospital, we focus on providing management of acute and chronic pain for newborns to adolescents who suffer from sickle cell anemia. Not only are we able to help families with the necessary education and maintenance with sickle cell anemia, but we also provide a variety of treatments that include IV pain medication, IV hydration, transfusions and the latest in pain therapy.

The Sickle Cell Day Treatment and Wellness Center provides all day medical treatment in a clinical outpatient setting. Our family-centered approach is aimed at comforting patients and their families and avoiding hospitalization. Children who do require ongoing care can be admitted to the hospital by a pediatric oncologist and pediatric nurses help the patient through their urgent situation.

We are currently in an ongoing compliance clinical trial with Exjade, a medication found effective in treating iron overload from blood transfusions in children and young adults ages five through 20 with sickle cell anemia. Exjade binds to iron and removes it from the blood stream. These formulated tablets are dispersed in a drink, allowing a convenient administration for our pediatric patients.

Our clinical trial team provides healthcare information, check-ups and interventions for the children and young adults in our community.  Our sickle cell specialty nurses are available to help patients stay informed and prevent pain before it becomes a problem. To speak to our nurse or for more information on sickle cell anemia, please call The Sickle Cell Day Treatment and Wellness Center at 954-712-2994.

What You Should Do...
Before pain becomes a problem, you can call the sickle cell nurse or speak to a physician who is on-call 24 hours a day, seven days a week or for more information on the Sickle Cell Day Treatment and Wellness Center, call 954-712-2994.

Day Hospital Hours
8 a.m. – 5 p.m., Monday – Friday, (excluding holidays)
Arrive for treatment before 2 p.m.